I think this is from the movie Thank You For Smoking. I think about it all the time. They were discussing having a paid advertisement of an astronaut smoking in a space station. One character points out it wouldn’t work because of the pure oxygen environment being explosive. The other character responds “We’ll just say ‘oh thank God we invented the whatever device!’” It’s sort of become an in joke with my wife about rough edges of plots in sequels.

I haven’t played any of the games, so I don’t really know why they couldn’t.